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Available out of hours. Contact the Media Relations Team +44 (0)20 7679 9041 or +44 (0)7917 271 364

Professor Nikolai Naoumov

Professor Nikolai Naoumov

Honorary Professor

Department : Div of Medicine

Faculty : Faculty of Medical Sciences

Address : 01.4054 FIRST FLOOR
ROYAL FREE HOSPITAL
ROWLAND HILL ST
HAMPSTEAD - LONDON
NW3 2PF

Languages spoken fluently (other than English) : None specified

None specified

Expert's Details expand all sections Expand Allcollapse all sections Collapse All

collapse section Keywords:

None specified

collapse section Research Interests, Expertise and Groups:

By better understanding the mechanisms of virus-host interactions, the goal is to develop more effective and individualised treatment regimens for patients with viral hepatitis. Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are the principal cause of chronic hepatitis, cirrhosis and liver cancer worldwide. By combining laboratory science (molecular biology and immunology) with clinical studies, the projects aiming to improve treatment outcomes and benefit patients.

Research groups:

Institute of Hepatology, Viral Hepatitis Group

Research publications:

Recent Publications:

Phillips S, Chokshi S, Riva A, Evans A, Williams R, Naoumov NV. CD8(+) T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functions. J Immunol. 2010;184(1)Virak: 287-95.

Pachiadakis I, Chokshi S, Cooksley H, Farmakiotis D, Sarrazin C, Zeuzem S, Michalak TI, Naoumov NV. Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions. Clin Immunol. 2009;131(3):415-25.

Liaw YF, Gane E, Leung N, Zeuzem S, Wang Y, Lai CL, Heathcote EJ, Manns M, Bzowej N, Niu J, Han SH, Hwang SG, Cakaloglu Y, Tong MJ, Papatheodoridis G, Chen Y, Brown NA, Albanis E, Galil K, Naoumov NV. 2-Year GLOBE trial results: telbivudine Is superior to lamivudine in patients with chronic hepatitis B. Gastroenterology. 2009;136(2):486-95.

Evans A, Riva A, Cooksley H, Phillips S, Puranik S, Nathwani A, Brett S, Chokshi S, Naoumov NV. Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion. Hepatology. 2008;48(3):759-69.

Thurairajah PH, Hegazy D, Chokshi S, Shaw S, Demaine A, Kaminski ER, Naoumov NV, Cramp ME. Hepatitis C virus (HCV)--specific T cell responses in injection drug users with apparent resistance to HCV infection. J Infect Dis. 2008;198(12):1749-55.

Cooksley H, Chokshi S, Maayan Y, Wedemeyer H, Andreone P, Gilson R, Warnes T, Paganin S, Zoulim F, Frederick D, Neumann AU, Brosgart CL, Naoumov NV. Hepatitis B e Antigen Loss During Adefovir Dipivoxil Therapy Is Associated With Enhanced Virus-Specific CD4+ T-Cell Reactivity. Antimicrob Agents Chemother. 2008;52(1):312-20.

Lai CL, Gane E, Liaw YF, Hsu CW, Thongsawat S, Wang Y, Chen Y, Heathcote EJ, Rasenack J, Bzowej N, Naoumov NV, Di Bisceglie AM, Zeuzem S, Moon YM, Goodman Z, Chao G, Constance BF, Brown NA; Globe Study Group. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med. 2007;357(25):2576-88.

Dal Pero F, Tang KH, Gerotto M, Bortoletto G, Paulon E, Herrmann E, Zeuzem S, Alberti A, Naoumov NV. Impact of NS5A sequences of Hepatitis C virus genotype 1a on early viral kinetics during treatment with peginterferon- alpha 2a plus ribavirin. J Infect Dis. 2007;196(7):998-1005.

Rigopoulou EI, Abbott WG, Williams R, Naoumov NV. Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus. Antiviral Res. 2007;75(1):36-42.

Rehermann B, Naoumov NV. Immunological techniques in viral hepatitis. J Hepatol. 2007;46(3): 508-20.

Personal web address: None specified

collapse section Professional Affiliations and Appointments:

Novartis Pharma AG, Global Head Hepatitits, Immunology and Infectious Diseases, Basel CH-4002, Switzerland

collapse section Media Experience:

Radio YesPrint Yes TV Yes

Example news stories:

None specified

Example video clips:

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