B250 Biology of Development 2001
ANSWER FOUR QUESTIONS
1. How has the study of Drosophila segmentation helped us understand
patterning of the vertebrate neural tube?
2. Outline the
principles of how axons find their targets during nervous system development,
and describe EITHER formation of the retino-tectal map OR how commissural axon
pathways are established in the ventral neural tube.
3. Write an essay on
branching morphogenesis.
4. Describe the genetics
of the Bithorax Complex (BX‑C) of Drosophila and explain how the Lewis model can
be reconciled with the known arrangement of genes.
5. Write an essay on sex
determination in mammals.
6. Describe how the
embryonic axes of the amphibian embryo are established by maternal gene
products.
7. Write an essay on
gametogenesis and fertilization.
8. Describe
pre-implantation development of the mouse. Explain how embryonic stem (ES) cells are derived and how
they can be used to manipulate gene expression in mice.
END OF PAPER