B250 Biology of Development
2001
ANSWER FOUR QUESTIONS in THREE HOURS
1. How
has the study of Drosophila segmentation helped us understand patterning
of the vertebrate neural tube?
2.
Outline the principles of how axons find their targets during nervous
system development, and describe EITHER formation of the retino-tectal
map OR how commissural axon pathways are established in the ventral neural
tube.
3.
Write an essay on branching morphogenesis.
4.
Describe the genetics of the Bithorax Complex
(BX‑C) of Drosophila and explain how the Lewis model can be
reconciled with the known arrangement of genes.
5.
Write an essay on sex determination in mammals.
6.
Describe how the embryonic axes of the amphibian embryo are established
by maternal gene products.
7.
Write an essay on gametogenesis and
fertilization.
8.
Describe pre-implantation development of the mouse. Explain how embryonic stem (ES) cells are
derived and how they can be used to manipulate gene expression in mice.
END OF PAPER