UCL Cancer Institute Seminar Series
19 November 2015, 12:00 pm–1:00 pm
Event Information
Location
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UCL Cancer Institute
Professor Kairbaan Hodivala-Dilke, Barts Cancer Institute, presents: Tumour angiogenesis, New ways, new roads. Thursday 19th November, 12pm
Anti-angiogenic agents have not produced widespread clinical benefits. By inhibiting cytotoxic drug delivery and elevating tumour hypoxia, anti-angiogenic approaches reduce the chemotherapy efficacy whilst increasing the tumour aggressiveness. Vascular normalization is a strategy to enhance the anti-tumour effects of chemotherapeutics, but this is time- and dose-dependent and therefore difficult to implement clinically. Here we establish, using methods distinct from anti-angiogenic or vascular normalization strategies, that a radical approach of ‘vascular promotion therapy’, using low dose Cilengitide and Verapamil, in combination with Gemcitabine, provides substantial advantages for cancer therapy. Our data challenge previous dogma and indicate proof-of-principle that vascular promotion could be a strategy to improve cancer therapy beyond standard therapy, thus opening a field of future research.
Hosted by Professor Bart Vanhaesebroeck
The seminar will be followed by a sandwich buffet lunch
References
1. Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong P-P, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG, & & Hodivala-Dilke KM. Endothelial-FAK is required for the maintenance of chemoresistance. Nature 2014 Jul 27. doi: 10.1038/nature13541.
2. Birdsey G, Shah A, Reynolds LE, Dufton N, Almagro L, Yang Y, Aspalter I, Khan S, Mason J, Dejana E, Göttgens B, Hodivala-Dilke KM, Gerhardt H, Adams RH, & Randi AM. (2015) The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/?-catenin signalling.Developmental Cell Jan 12;32(1):82-96
3. Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford M, Scudamore C, Cereser B, Elia G, Hagemann T, Kocher HM, and Hodivala-Dilke KM. Low concentration RGD-integrin inhibitor enhances the efficacy of gemcitabine Cancer Cell. Jan 12;27(1):123-37.
Location
UCL Cancer Institute
Courtyard Café
Paul O'Gorman Building
72 Huntley Street
London, WC1E 6DD