Research Projects

An A-Z list of the Research Projects within IGH

A-C

AMBER: A Phase 3, randomized, active-controlled, double-blind study to evaluate efficacy and safety of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) once daily fixed dose combination regimen versus a regimen consisting of darunavir/cobicistat fixed dose combination coadministered with emtricitabine/tenofovir disoproxil fumarate fixed dose combination in antiretroviral treatment-naïve human immunodeficiency virus type 1 infected subjects. (TMC114FD2HTX3001)

Analysis of the Impact of Anaemia Reduction and Control Strategies in Emergency-Affected Refugee Populations

Assessing the impact of introducing online postal self-sampling for sexually transmitted infections into sexual health provision within the UK on health inequalities, access to care and clinical outcomes (ASSIST)

Barriers, facilitators and preferences for HIV prevention in people experiencing homelessness

BESTT Women's Study: Bone Evaluation in HIV-positive women who switch from Truvada/NNRTI to Triumeq

British HIV Association (BHIVA) COVID-19 Registry

CARE: Diabetes in Ghana

CASCADE

China Lancet Countdown Case Study

Community Survey of the experiences of COVID-19 on people living with HIV in the UK

Cultural hierarchies in health

D-F

Developing a Scalable Programme to Promote Early Childhood Nutrition and Development in Rural Uganda: A Feasibility Study

Disability and Disaster

DISCOVER: A Phase 3, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex with Men and Are At Risk of HIV-1 Infection (GS-US-412-2055)

EMERALD: a randomized, active-controlled, open-label study to evaluate the efficacy and safety of switching to a D/C/F/TAF once-daily single-tablet regimen versus continuing the current regimen consisting of a boosted protease inhibitor (bPI) combined with FTC/TDF

EuroSIDA: A prospective observational cohort study of HIV-positive individuals in Europe, Israel and Argentina

EuroSIDA/MISTRAL

EVE Project: Evidence for Violence prevention in the Extreme

FLAIR: A Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants

G-I

GS-US-380-1489: A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of GS-9883/Emtricitabine/Tenofovir Alafenamide Versus Abacavir/Dolutegravir/Lamivudine in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults

GS-US-380-1490: A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of GS-9883/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir + Emtricitabine/Tenofovir Alafenamide in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults

HIPvac: Randomised controlled trial of Imiquimod cream vs. podophyllotoxin in combination with quadrivalent HPV or control vaccination in the treatment and prevention of recurrence of anogenital warts

HIV BioResource

HPV Sampling Study

Icona Network

The Integrated Sustainable Childhood Pneumonia and Infectious disease Reduction in Nigeria (INSPIRING) programme evaluation and research

International SARS-CoV-2 Infection Observational Study (ICOS)

J-L

Lancet Countdown: tracking progress on health and climate change

LISTEN

Locally grounded, transnationally queer

M-O

Many Strong Voices bringing together the peoples of the Arctic and Small Island Developing States to meet the challenges of climate change including health

Maternal and newborn care practices among disabled women, and their attendance in community groups in rural Makwanpur, Nepal

MAVMET: A multicentre, 48 week randomised controlled factorial trial of adding maraviroc and/or metformin for hepatic steatosis in HIV-1-infected adults on combination antiretroviral therapy

Migration and Xenophobia in Schools (MIXES)

Mobilising for anxiety and depression in adolescents (MADAD)

Modelling and cost effectiveness analysis to inform response to high levels of HIV drug resistance in sub-Saharan Africa, including deployment of new drug regimens (HIV Synthesis Model)

NATSAL: The National Survey of Sexual Attitudes and Lifestyles

Needs Informed model of Care for people living with HIV (NICHE)

NICHE

P-R

Pantheon 2

PERSIMUNE: Centre of excellence for personalised medicine of infectious complications in immune deficiency

Pharmacokinetics-Pharmacodynamics Group

The POPPY (Pharmacokinetic and clinical Observations in PeoPle over fiftY) Study

POPPY Sleep Substudy: study looking at the effects of being HIV positive and being on antiretroviral medication may have on sleeping and sleep pattern

PrEP IMPACT Trial: A pragmatic health technology assessment of PrEP and implementation

Race & Health

RESPOND Africa

RID-TB: Research to Improve Detection and Treatment of Latent TB Infection

Royal Free HIV Cohort Study

S-U

Safetxt: A randomised controlled trial of an intervention delivered by mobile phone messaging to reduce sexually transmitted infections (STI) by increasing sexual health precaution behaviours in young people

SEPAC: Screening and early detection to prevent anal cancer; development of a biomarker screening tool

SEQUENCE digital - Sexual health equity through evidence-based online clinical care (Improving sexual health for all, in a digital NHS)

Sixhumene: Using social networks to understand and intervene on HIV epidemic spread

STOP HCV-1: Stratified Treatment OPtimisation for HCV-1: An open-label randomised controlled trial (RCT) testing biomarker-stratified short-course first-line and re-treatment direct-acting antiviral (DAA) oral treatment regimens to cure mild chronic Hepatitis C (HCV) disease

T-pal-Omics Study: Syphilis Transcriptomics: Proof of concept study that aims to utilise next generation sequencing and transcriptomic approaches to understand infection with Treponema pallidum

TANGO: A Phase III, randomized, multicenter, parallel-group, non-inferiority study evaluating the efficacy, safety, and tolerability of switching to dolutegravir plus lamivudine in HIV-1-infected adults who are virologically suppressed

TB:HIV - Tuberculosis among HIV-positive Patients: An International Prospective Observational Cohort Study

TB-IPD Platform

Testing a community based intervention to reduce neonatal deaths in rural Ghana: Newborn Home Intervention Study (Newhints)

The UK National Menopause Education and Support Programme

The Ties That Bind

UK Lancet Countdown Case Study

V-W

Verbal Autopsy through the use of Mobile Phones: What is the acceptability and feasibility of giving cause of death information generated by Mobile InterVA to families of the deceased in rural Nepal?

VITA: A randomised controlled trial to assess the clinical and cost effectiveness of topical lactic acid gel for treating second and subsequent episodes of bacterial vaginosis