Genetic Determinants of Antimicrobial Resistance in Enterococcus, a Major Urinary Pathogen

This collaboration seeks to understand the relationship between gene presence or absence and antibiotic susceptibility

Genus Enterococcus is one of the major causes of recurrent urinary tract infections (UTIs). The aim of the project is to understand the relationship between gene presence/absence and antibiotic susceptibility in 73 Enteroccoccus isolates obtained from three cohorts: elderly patients, renal-transplant recipients, and healthy individuals. Having next-generation sequencing data already generated for all samples, after genome assembly and annotation of the pan-genomes, the project will aim to link gene carriage to resistance phenotypes measured in lab culture assays. In parallel, a video showcasing the research (aimed at a general audience) will be featured on the Institute of Child Health YouTube Channel.