World-first use of base-edited CAR T-cells to treat resistant leukaemia

A patient with relapsed T-cell leukaemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a ‘bench-to-bedside’ collaboration between researchers at UCL, led by Professor Waseem Qasim and Great Ormond Street Hospital for Children (GOSH).

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