Carbon-Carbon Correlations

In the majority of cases a joint analysis of ¹H,¹H COSY and ¹H,¹³C HMBC spectra is sufficient for structure elucidations of organic compounds. In some cases, however, ¹³C,¹³C correlations may be needed in order to determine the structure unambiguously. The availability of the ¹³C-optimised cryoprobe allows to carry out experiments relying on J(C,C)-couplings within reasonable time frame. As an example, the 2D INADEQUATE spectrum (INAD2D under IconNMR) of the concentrated solution of menthol was acquired in 54 minutes:

 Click here for the high-resolution version.

2D INADEQUATE experiment can also be used to detect connectivities of other nuclei. For example, ³¹P-³¹P correlations can be verified using the 400 MHz instrument.

A one-dimensional version of INADEQUATE is also available, which allows accurate measurements of J(C,C) couplings.