2024 Publications

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The 2023 UN high-level meeting on tuberculosis: Renewing hope, momentum, and commitment to end tuberculosis. (2024) Millington, K. A., White, R. G., Lipman, M., McQuaid, C. F., Hauser, J., Wooding, V., Potter, J., Abubakar, I., and Wingfield, T. Lancet Respir Med 12, 10-13: https://doi.org/10.1016/S2213-2600(23)00409-5.

Acetic acid enables molecular enumeration of Mycobacterium tuberculosis from sputum and eliminates the need for a Biosafety Level 3 laboratory. (2024) Palekyte, A., Morkowska, A., Billington, O., Morris-Jones, S., Millard, J., Marakalala, M. J., Owolabi, O., Sambou, B., Zumla, A., Sutherland, J. S., McHugh, T. D., and Honeyborne, I. Clin Chem 70, 642-652: https://doi.org/10.1093/clinchem/hvae013.

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles. (2024) Krause, R., Ogongo, P., Tezera, L., Ahmed, M., Mbano, I., Chambers, M., Ngoepe, A., Magnoumba, M., Muema, D., Karim, F., Khan, K., Lumamba, K., Nargan, K., Madansein, R., Steyn, A., Shalek, A. K., Elkington, P., and Leslie, A. Commun Biol 7, 584: https://doi.org/10.1038/s42003-024-06282-7.

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery. (2024) Bonjorno, A. F., Pavan, A. R., Fernandes, G. F. S., Scarim, C. B., Castagnolo, D., and Dos Santos, J. L. Front Chem 12, 1358539: https://doi.org/10.3389/fchem.2024.1358539.

Bedaquiline-pretomanid-moxifloxacin-pyrazinamide for drug-sensitive and drug-resistant pulmonary tuberculosis treatment: a phase 2c, open-label, multicentre, partially randomised controlled trial. (2024) Cevik, M., Thompson, L. C., Upton, C., Rolla, V. C., Malahleha, M., Mmbaga, B., Ngubane, N., Abu Bakar, Z., Rassool, M., Variava, E., Dawson, R., Staples, S., Lalloo, U., Louw, C., Conradie, F., Eristavi, M., Samoilova, A., Skornyakov, S. N., Ntinginya, N. E., Haraka, F., Praygod, G., Mayanja-Kizza, H., Caoili, J., Balanag, V., Dalcolmo, M. P., McHugh, T., Hunt, R., Solanki, P., Bateson, A., Crook, A. M., Fabiane, S., Timm, J., Sun, E., Spigelman, M., Sloan, D. J., Gillespie, S. H., and Simplici, T. B. C. Lancet Infect Dis 24, 1003-1014: https://doi.org/10.1016/S1473-3099(24)00223-8.

Bioarchaeological investigation of individuals with suspected multibacillary leprosy from the mediaeval leprosarium of St Mary Magdalen, Winchester, Hampshire, UK. (2024) Taylor, G. M., White-Iribhogbe, K., Cole, G., Ashby, D., Stewart, G. R., and Dawson-Hobbis, H. J Med Microbiol 73 https://doi.org/10.1099/jmm.0.001806.

Blazing the trail for innovative tuberculosis diagnostics. (2024) Yerlikaya, S., Broger, T., Isaacs, C., Bell, D., Holtgrewe, L., Gupta-Wright, A., Nahid, P., Cattamanchi, A., and Denkinger, C. M. Infection 52, 29-42: https://doi.org/10.1007/s15010-023-02135-3.

Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study. (2024) Mann, T., Gupta, R. K., Reeve, B. W. P., Ndlangalavu, G., Chandran, A., Krishna, A. P., Calderwood, C. J., Tshivhula, H., Palmer, Z., Naidoo, S., Mbu, D. L., Theron, G., and Noursadeghi, M. Lancet Glob Health 12, e783-e792: https://doi.org/10.1016/S2214-109X(24)00029-9.

Characteristics and phenotypes of a COPD cohort from referral hospital clinics in Uganda. (2024) Alupo, P., Mugenyi, L., Katagira, W., Kayongo, A., Nalunjogi, J., Siddharthan, T., Hurst, J. R., Kirenga, B., and Jones, R. BMJ Open Respir Res 11 https://doi.org/10.1136/bmjresp-2023-001816.

Classification of early tuberculosis states to guide research for improved care and prevention: an international Delphi consensus exercise. (2024) Coussens, A. K., Zaidi, S. M. A., Allwood, B. W., Dewan, P. K., Gray, G., Kohli, M., Kredo, T., Marais, B. J., Marks, G. B., Martinez, L., Ruhwald, M., Scriba, T. J., Seddon, J. A., Tisile, P., Warner, D. F., Wilkinson, R. J., Esmail, H., Houben, R., and International Consensus for Early, T. B. g. Lancet Respir Med https://doi.org/10.1016/S2213-2600(24)00028-6.

Clinical application of whole-genome sequencing in the management of extensively drug-resistant tuberculosis: a case report. (2024) Katale, B. Z., Rofael, S., Elton, L., Mbugi, E. V., Mpagama, S. G., Mtunga, D., Mafie, M. G., Mbelele, P. M., Williams, C., Mvungi, H. C., Williams, R., Saku, G. A., Ruta, J. A., McHugh, T. D., and Matee, M. I. Ann Clin Microbiol Antimicrob 23, 76: https://doi.org/10.1186/s12941-024-00737-9.

Clinical outcomes in children living with HIV treated for non-severe tuberculosis in the SHINE Trial. (2024) Chabala, C., Wobudeya, E., van der Zalm, M. M., Kapasa, M., Raichur, P., Mboizi, R., Palmer, M., Kinikar, A., Hissar, S., Mulenga, V., Mave, V., Musoke, P., Hesseling, A. C., McIlleron, H., Gibb, D., Crook, A., Turkova, A., and team, S. t. Clin Infect Dis https://doi.org/10.1093/cid/ciae193.

Community views on active case finding for tuberculosis in low- and middle-income countries: a qualitative evidence synthesis. (2024) Taylor, M., Medley, N., van Wyk, S. S., and Oliver, S. Cochrane Database Syst Rev 3, CD014756: https://doi.org/10.1002/14651858.CD014756.pub2.

Comparing priority received by global health issues: a measurement framework applied to tuberculosis, malaria, diarrhoeal diseases and dengue fever. (2024) Parashar, R., Nanda, S., Smith, S. L., Shroff, Z., Shawar, Y. R., Hamunakwadi, D. L., and Shiffman, J. BMJ Glob Health 9https://doi.org/10.1136/bmjgh-2023-014884.

Detailed phenotyping reveals diverse and highly skewed neutrophil subsets in both the blood and airways during active tuberculosis infection. (2024) Nhamoyebonde, S., Chambers, M., Ndlovu, L., Karim, F., Mazibuko, M., Mhlane, Z., Madziwa, L., Moosa, Y., Moodley, S., Hoque, M., and Leslie, A. Front Immunol 15, 1422836: https://doi.org/10.3389/fimmu.2024.1422836.

Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis. (2024) Nimmo, C., Ortiz, A. T., Tan, C. C. S., Pang, J., Acman, M., Millard, J., Padayatchi, N., Grant, A. D., O'Donnell, M., Pym, A., Brynildsrud, O. B., Eldholm, V., Grandjean, L., Didelot, X., Balloux, F., and van Dorp, L. Genome Med 16, 34: https://doi.org/10.1186/s13073-024-01289-5.

Detection of M. tuberculosis DNA in TB contacts' PBMC does not associate with blood RNA signatures for incipient tuberculosis. (2024) Rosenheim, J., Abebe, M., Belay, M., Tulu, B., Tayachew, D., Tegegn, M., Younis, S., Jolliffe, D. A., Aseffa, A., Ameni, G., Reece, S. T., Noursadeghi, M., and Martineau, A. R. Eur Respir J https://doi.org/10.1183/13993003.00479-2024.

Diagnosis of tuberculosis infection in children with a novel skin test and the traditional tuberculin skin test: An observational study. (2024) Fritschi, N., Gureva, T., Eliseev, P., Jackson, C., Milanzi, E., Crichton, S., Collins, I. J., Turkova, A., Mariandyshev, A., and Ritz, N. PLoS One 19, e0293272: https://doi.org/10.1371/journal.pone.0293272.

Diagnosis and management of tuberculosis infection in inclusion health populations in London. (2024) Gray, A., Surey, J., Veitch, M., Menezes, D., Gibbons, J., Leonard, M., Sultan, B., Esmail, H., and Story, A. BMC Infect Dis 24, 252: https://doi.org/10.1186/s12879-024-09132-3.

Diagnostic accuracy of a three-gene Mycobacterium tuberculosis host response cartridge using fingerstick blood for childhood tuberculosis: A multicentre prospective study in low-income and middle-income countries. (2024) Olbrich, L., Verghese, V. P., Franckling-Smith, Z., Sabi, I., Ntinginya, N. E., Mfinanga, A., Banze, D., Viegas, S., Khosa, C., Semphere, R., Nliwasa, M., McHugh, T. D., Larsson, L., Razid, A., Song, R., Corbett, E. L., Nabeta, P., Trollip, A., Graham, S. M., Hoelscher, M., Geldmacher, C., Zar, H. J., Michael, J. S., Heinrich, N., and RaPaed, T. B. c. Lancet Infect Dis 24, 140-149: https://doi.org/10.1016/S1473-3099(23)00491-7.

Drug-induced hepatotoxicity and association with slow acetylation variants NAT2*5 and NAT2*6 in Cameroonian patients with tuberculosis and HIV co-infection. (2024) Cho, F. N., Achidi, E. A., Enoh, J. E., Pallerla, S. R., Linh, L. T. K., Tong, H. V., Kamgno, J., Penlap, V. B., Adegnika, A. A., Lekana-Douki, J. B., Bouyou-Akotet, M. K., Kahunu, G. M., Lutete, G. T., Bates, M., Tembo, J., Elton, L., McHugh, T. D., Grobusch, M. P., Zumla, A., Ntoumi, F., and Velavan, T. P. BMC Infect Dis 24, 759: https://doi.org/10.1186/s12879-024-09638-w.

Drug-resistant tuberculosis treatments, the case for a phase III platform trial. (2024) Yates, T. A., Barnes, S., Dedicoat, M., Kon, O. M., Kunst, H., Lipman, M., Millington, K. A., Nunn, A. J., Phillips, P. P., Potter, J. L., Squire, S. B., Academics, U. K., and Professionals to end, T. B. Bull World Health Organ 102, 657-664: https://doi.org/10.2471/BLT.23.290948.4.

The effect of HIV on the association of hyperglycaemia and active tuberculosis in Zambia, a case-control study. (2024) Bailey, S. L., Floyd, S., Cheeba-Lengwe, M., Maluzi, K., Chiwele-Kangololo, K., Kaluba-Milimo, D., Amofa-Sekyi, M., Yudkin, J. S., Godfrey-Faussett, P., and Ayles, H. J Epidemiol Glob Health https://doi.org/10.1007/s44197-024-00236-2.

Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter? (2024) Nardotto, G. H. B., Svenson, E. M., Bollela, V. R., Rocha, A., Slavov, S. N., Ximenez, J. P. B., Della Pasqua, O., and Lanchote, V. L. Pharmaceutics 16 https://doi.org/10.3390/pharmaceutics16080970.

The end of the road for blood RNA biomarkers as triage tests for symptomatic pulmonary tuberculosis among spontaneous sputum producers? (2024) Greenan-Barrett, J., Gupta, R. K., and Noursadeghi, M. Eur Respir J 64https://doi.org/10.1183/13993003.01365-202

Enhanced tuberculosis diagnosis with computer-aided chest X-ray and urine LAM in adults with HIV admitted to hospital (CASTLE study): A cluster randomised trial. (2024) Burke, R. M., Nyirenda, S. K., Mtenga, T., Twabi, H. H., Joekes, E., Walker, N. F., Nyirenda, R., Gupta-Wright, A., Nliwasa, M., Fielding, K., MacPherson, P., and Corbett, E. L. Clin Infect Dis https://doi.org/10.1093/cid/ciae273.

Evaluation of serological assays for the diagnosis of childhood tuberculosis disease: a study protocol. (2024) Neudecker, D., Fritisch, N., Sutter, T., Lu, L., Lu, P., Tebruegge, M., Santiago-Garcia, B., and Ritz, N. BMC Infect Dis 24, 481: https://doi.org/10.1186/s12879-024-09359-0.

Evaluation of the Xpert MTB Host Response assay for the triage of patients with presumed pulmonary tuberculosis: A prospective diagnostic accuracy study in Viet Nam, India, the Philippines, Uganda, and South Africa. (2024) Gupta-Wright, A., Ha, H., Abdulgadar, S., Crowder, R., Emmanuel, J., Mukwatamundu, J., Marcelo, D., Phillips, P. P. J., Christopher, D. J., Nhung, N. V., Theron, G., Yu, C., Nahid, P., Cattamanchi, A., Worodria, W., Denkinger, C. M., and Network, R. D. T. Lancet Glob Health 12, e226-e234: https://doi.org/10.1016/S2214-109X(23)00541-7.

Editorial: The evolution in pharmacology of infectious diseases: 2022. (2024) Porta, E. O. J., Saffaei, A., and Kalesh, K. Front Pharmacol 15, 1386077: https://doi.org/10.3389/fphar.2024.1386077.

A flexible multi-metric Bayesian framework for decision-making in Phase II multi-arm multi-stage studies. (2024) Dufault, S. M., Crook, A. M., Rolfe, K., and Phillips, P. P. J. Stat Med 43, 501-513: https://doi.org/10.1002/sim.9961.

Geographical targeting of active case finding for tuberculosis in Pakistan using hotspots identified by artificial intelligence software (SPOT-TB): study protocol for a pragmatic stepped wedge cluster randomised control trial. (2024) Zaidi, S. M. A., Mahfooz, A., Latif, A., Nawaz, N., Fatima, R., Rehman, F. U., Reza, T. E., and Emmanuel, F. BMJ Open Respir Res 11https://doi.org/10.1136/bmjresp-2023-002079.

A Global Tuberculosis Dictionary: unified terms and definitions for the field of tuberculosis. (2024) Garcia-Basteiro, A. L., Ehrlich, J., Bonnet, M., Calnan, M., Graham, S. M., Hermans, S., Jarrett, A., Lewa, R., Mandalakas, A., Martinez, L., Migliori, G. B., Ong, C. W. M., Otero, L., Rangaka, M. X., Raviglione, M. C. B., Seaworth, B., Ssengooba, W., Theron, G., Trajman, A., and Behr, M. A. Lancet Glob Health 12, e737-e739: https://doi.org/10.1016/S2214-109X(24)00083-4.

Health and illness beliefs in adults with tuberculosis infection during the COVID-19 pandemic in the UK. (2024) Kilic, A., Clarke, A. L., Moon, Z., Hamada, Y., Chan, A. H. Y., Rahman, A., Layton, C., Griffiths, C. J., Zenner, D., Powell, E., Kunst, H., Lipman, M., Mandelbaum, M., Papineni, P., Tattersall, T., Duong, T., Abubakar, I., Rangaka, M. X., and Horne, R. Dialogues Health 4, 100162: https://doi.org/10.1016/j.dialog.2023.100162.

Healthcare provisions associated with multiple HIV-related outcomes among adolescent girls and young women living with HIV in South Africa: a cross-sectional study. (2024) Toska, E., Zhou, S., Laurenzi, C. A., Saal, W., Rudgard, W., Wittesaele, C., Langwenya, N., Jochim, J., Banougnin, B. H., Gulaid, L., Armstrong, A., Sherman, G., Edun, O., Sherr, L., and Cluver, L. J Int AIDS Soc 27, e26212: https://doi.org/10.1002/jia2.26212.

Heteroresistance in tuberculosis: are we missing drug-resistant bacteria hiding in plain sight? (2024) Park, M., Satta, G., and Haldar, P. Thorax https://doi.org/10.1136/thorax-2024-221409.

HIV, multimorbidity, and health-related quality of life in rural KwaZulu-Natal, South Africa: A population-based study. (2024) Stanton, A. M., Boyd, R. L., O'Cleirigh, C., Olivier, S., Dolotina, B., Gunda, R., Koole, O., Gareta, D., Modise, T. H., Reynolds, Z., Khoza, T., Herbst, K., Ndung'u, T., Hanekom, W. A., Wong, E. B., Pillay, D., Siedner, M. J., and Vukuzazi Study, T. PLoS One 19, e0293963: https://doi.org/10.1371/journal.pone.0293963.

Identification and design of novel potential antimicrobial peptides targeting mycobacterial protein kinase PknB. (2024) Deka, H., Pawar, A., Battula, M., Ghfar, A. A., Assal, M. E., and Chikhale, R. V. Protein J 43, 858-868: https://doi.org/10.1007/s10930-024-10218-9.

Identification and molecular characterization of Mycobacterium bovis DNA in GeneXpert(R) MTB/RIF ultra-positive, culture-negative sputum from a rural community in South Africa. (2024) Goosen, W. J., Moodley, S., Ghielmetti, G., Moosa, Y., Zulu, T., Smit, T., Vukuzazi, T., Kleynhans, L., Kerr, T. J., Streicher, E. M., Hanekom, W. A., Warren, R. M., Wong, E. B., and Miller, M. A. One Health 18, 100702: https://doi.org/10.1016/j.onehlt.2024.100702.

Identification of mycobacterial Thymidylate kinase inhibitors: a comprehensive pharmacophore, machine learning, molecular docking, and molecular dynamics simulation studies. (2024) Chikhale, R. V., Pawar, S. P., Kolpe, M. S., Shinde, O. D., Dahlous, K. A., Mohammad, S., Patil, P. C., and Bhowmick, S. Mol Divershttps://doi.org/10.1007/s11030-024-10967-w.

Identification of Mycobacterium tuberculosis transcriptional repressor EthR inhibitors: Shape-based search and machine learning studies. (2024) Chikhale, R. V., Eldesoky, G. E., Kolpe, M. S., Suryawanshi, V. S., Patil, P. C., and Bhowmick, S. Heliyon 10, e26802: https://doi.org/10.1016/j.heliyon.2024.e26802.

Identification of novel hit molecules targeting M. tuberculosis polyketide synthase 13 by combining generative AI and physics-based methods. (2024) Chikhale, R. V., Choudhary, R., Malhotra, J., Eldesoky, G. E., Mangal, P., and Patil, P. C. Comput Biol Med 176, 108573: https://doi.org/10.1016/j.compbiomed.2024.108573.

Implications of subclinical tuberculosis for vaccine trial design and global effect. (2024) Churchyard, G. J., Houben, R., Fielding, K., Fiore-Gartland, A. L., Esmail, H., Grant, A. D., Rangaka, M. X., Behr, M., Garcia-Basteiro, A. L., Wong, E. B., Hatherill, M., Mave, V., Dagnew, A. F., Schmidt, A. C., Hanekom, W. A., Cobelens, F., and White, R. G. Lancet Microbe https://doi.org/10.1016/S2666-5247(24)00127-7.

Improving the diagnosis of tuberculosis: old and new laboratory tools. (2024) Solanki, P., Elton, L., Honeyborne, I., Park, M., Satta, G., and McHugh, T. D. Expert Rev Mol Diagn 24, 487-496: https://doi.org/10.1080/14737159.2024.2362165.

Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers. (2024) Schiff, H. F., Walker, N. F., Ugarte-Gil, C., Tebruegge, M., Manousopoulou, A., Garbis, S. D., Mansour, S., Wong, P. H. M., Rockett, G., Piazza, P., Niranjan, M., Vallejo, A. F., Woelk, C. H., Wilkinson, R. J., Tezera, L. B., Garay-Baquero, D., and Elkington, P. JCI Insight 9 https://doi.org/10.1172/jci.insight.173273.

Integrating molecular microbial methods to improve faecal pollution management in rivers with designated bathing waters. (2024) Karunakaran, E., Battarbee, R., Tait, S., Brentan, B. M., Berney, C., Grinham, J., Herrero, M. A., Omolo, R., and Douterelo, I. Sci Total Environ 912, 168565: https://doi.org/10.1016/j.scitotenv.2023.168565.

Integration and validation of host transcript signatures, including a novel 3-transcript tuberculosis signature, to enable one-step multiclass diagnosis of childhood febrile disease. (2024) Channon-Wells, S., Habgood-Coote, D., Vito, O., Galassini, R., Wright, V. J., Brent, A. J., Heyderman, R. S., Anderson, S. T., Eley, B., Martinon-Torres, F., Levin, M., Kaforou, M., Uk Kawasaki Disease Genetics, I. G., consortia, E., and Herberg, J. A. J Transl Med 22, 802: https://doi.org/10.1186/s12967-024-05241-4.

Isoniazid preventive therapy completion between July-September 2019: A comparison across HIV differentiated service delivery models in Uganda. (2024) Mugenyi, L., Namuwenge, P. M., Ouma, S., Bakashaba, B., Nanfuka, M., Zech, J., Agaba, C., Mijumbi Ojok, A., Kaliba, F., Bossa Kato, J., Opito, R., Miya, Y., Katureebe, C., and Hirsch-Moverman, Y. PLoS One 19, e0296239: https://doi.org/10.1371/journal.pone.0296239.

Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis. (2024) Abdelgawad, N., Wasserman, S., Abdelwahab, M. T., Davis, A., Stek, C., Wiesner, L., Black, J., Meintjes, G., Wilkinson, R. J., and Denti, P. J Infect Dis 229, 1200-1208: https://doi.org/10.1093/infdis/jiad413.

Liposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis. (2024) Maringolo Ribeiro, C., Augusto Roque-Borda, C., Carolina Franzini, M., Fernanda Manieri, K., Manaia Demarqui, F., Leite Campos, D., Temperani Amaral Machado, R., Cristiane da Silva, I., Tavares Luiz, M., Delello Di Filippo, L., Bento da Silva, P., Cristina Oliveira da Rocha, M., Nair Bao, S., Masci, D., Fernandes, G. F. S., Castagnolo, D., Chorilli, M., and Rogerio Pavan, F. Int J Pharm 655, 124050: https://doi.org/10.1016/j.ijpharm.2024.124050.

Localised erythema nodosum leprosum-A rare entity managed with thalidomide. (2024) Patel, C., De Barros, B., and Walker, S. L. Skin Health Dis 4, e339: https://doi.org/10.1002/ski2.339.

Machine learning assisted methods for the identification of low toxicity inhibitors of Enoyl-Acyl Carrier Protein Reductase (InhA). (2024) Chikhale, R. V., Abdelghani, H. T. M., Deka, H., Pawar, A. D., Patil, P. C., and Bhowmick, S. Comput Biol Chem 110, 108034: https://doi.org/10.1016/j.compbiolchem.2024.108034.

Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review. (2024) Fuller, N. M., McQuaid, C. F., Harker, M. J., Weerasuriya, C. K., McHugh, T. D., and Knight, G. M. PLoS Pathog 20, e1011574: https://doi.org/10.1371/journal.ppat.1011574.

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture. (2024) Schurz, H., Naranbhai, V., Yates, T. A., Gilchrist, J. J., Parks, T., Dodd, P. J., Moller, M., Hoal, E. G., Morris, A. P., Hill, A. V. S., and International Tuberculosis Host Genetics, C. Elife 13 https://doi.org/10.7554/eLife.84394.

Mycobacterial FtsEX-RipC interaction is required for normal growth and cell morphology in rifampicin and low ionic strength conditions. (2024) Samuels, V., Mulelu, A. E., Ndlovu, H., and Marakalala, M. J. Microbiol Spectr, e0251523: https://doi.org/10.1128/spectrum.02515-23.

The Mycobacterium tuberculosis cell wall: An alluring drug target for developing newer anti-TB drugs - A perspective. (2024) Chauhan, M., Barot, R., Yadav, R., Joshi, K., Mirza, S., Chikhale, R., Srivastava, V. K., Yadav, M. R., and Murumkar, P. R. Chem Biol Drug Des 104, e14612: https://doi.org/10.1111/cbdd.14612.

Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model. (2024) Ahmed, M., Tezera, L. B., Herbert, N., Chambers, M., Reichmann, M. T., Nargan, K., Kloverpris, H., Karim, F., Hlatshwayo, M., Madensein, R., Habesh, M., Hoque, M., Steyn, A. J. C., Elkington, P. T., and Leslie, A. J. Front Immunol 15, 1360412: https://doi.org/10.3389/fimmu.2024.1360412.

Need for high-resolution observational cohort studies to understand the natural history of tuberculosis. (2024) Larsson, L., Calderwood, C. J., Gupta, R. K., Khosa, C., and Kranzer, K. Lancet Microbe https://doi.org/10.1016/S2666-5247(24)00140-X.

Non-tuberculous mycobacterial pulmonary disease (NTM-PD): Epidemiology, diagnosis and multidisciplinary management. (2024) Kumar, K., Ponnuswamy, A., Capstick, T. G., Chen, C., McCabe, D., Hurst, R., Morrison, L., Moore, F., Gallardo, M., Keane, J., Harwood, S., Sinnett, T., Bryant, S., Breen, R., Kon, O. M., Lipman, M., Loebinger, M. R., and Dhasmana, D. J. Clin Med (Lond) 24, 100017: https://doi.org/10.1016/j.clinme.2024.100017.

A novel regulatory interplay between atypical B12 riboswitches and uORF translation in Mycobacterium tuberculosis. (2024) Kipkorir, T., Polgar, P., Barker, D., D'Halluin, A., Patel, Z., and Arnvig, K. B. Nucleic Acids Res https://doi.org/10.1093/nar/gkae338.

Optimizing the cascade of prevention to protect people from tuberculosis: A potential game changer for reducing global tuberculosis incidence. (2024) Matteelli, A., Churchyard, G., Cirillo, D., den Boon, S., Falzon, D., Hamada, Y., Houben, R., Kanchar, A., Kritski, A., Kumar, B., Miller, C., Menzies, D., and Masini, T. PLOS Glob Public Health 4, e0003306: https://doi.org/10.1371/journal.pgph.0003306.

Perspectives on development and advancement of new tuberculosis vaccines. (2024) da Costa, C., Benn, C. S., Nyirenda, T., Mpabalwani, E., Grewal, H. M. S., Ahmed, R., Kapata, N., Nyasulu, P. S., Maeurer, M., Hui, D. S., Goletti, D., and Zumla, A. Int J Infect Dis 141S, 106987: https://doi.org/10.1016/j.ijid.2024.106987.

Phenotype versus genotype discordant rifampicin susceptibility testing in tuberculosis: Implications for a diagnostic accuracy. (2024) Qadir, M., Faryal, R., Khan, M. T., Khan, S. A., Zhang, S., Li, W., Wei, D. Q., Tahseen, S., and McHugh, T. D. Microbiol Spectr 12, e0163123: https://doi.org/10.1128/spectrum.01631-23.

Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective, cross-sectional, diagnostic accuracy study. (2024) Reeve, B. W. P., Ndlangalavu, G., Mishra, H., Palmer, Z., Tshivhula, H., Rockman, L., Naidoo, S., Mbu, D. L., Naidoo, C. C., Derendinger, B., Walzl, G., Malherbe, S. T., van Helden, P. D., Semitala, F. C., Yoon, C., Gupta, R. K., Noursadeghi, M., Warren, R. M., and Theron, G. Lancet Glob Health 12, e793-e803: https://doi.org/10.1016/S2214-109X(24)00052-4.

Prevalence of non-communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta-analysis. (2024) Hamada, Y., Quartagno, M., Malik, F., Ntshamane, K., Tisler, A., Gaikwad, S., Acuna-Villaorduna, C., Bhavani, P. K., Alisjahbana, B., Ronacher, K., Apriani, L., Becerra, M., Chu, A. L., Creswell, J., Diaz, G., Ferro, B. E., Galea, J. T., Grandjean, L., Grewal, H. M. S., Gupta, A., Jones-Lopez, E. C., Kleynhans, L., Lecca, L., MacPherson, P., Murray, M., Marin, D., Restrepo, B. I., Shivakumar, S., Shu, E., Sivakumaran, D., Vo, L. N. Q., Webb, E. L., Copas, A., Abubakar, I., and Rangaka, M. X. Trop Med Int Health 29, 768-780: https://doi.org/10.1111/tmi.14038.

Prevalence of subclinical pulmonary tuberculosis in adults in community settings: an individual participant data meta-analysis. (2024) Stuck, L., Klinkenberg, E., Abdelgadir Ali, N., Basheir Abukaraig, E. A., Adusi-Poku, Y., Alebachew Wagaw, Z., Fatima, R., Kapata, N., Kapata-Chanda, P., Kirenga, B., Maama-Maime, L. B., Mfinanga, S. G., Moyo, S., Mvusi, L., Nandjebo, N., Nguyen, H. V., Nguyen, H. B., Obasanya, J., Adedapo Olufemi, B., Patrobas Dashi, P., Raleting Letsie, T. J., Ruswa, N., Rutebemberwa, E., Senkoro, M., Sivanna, T., Yuda, H. C., Law, I., Onozaki, I., Tiemersma, E., Cobelens, F., and sc, T. B. M. I. G. Lancet Infect Dis https://doi.org/10.1016/S1473-3099(24)00011-2.

Preventive therapy: can tuberculosis efforts learn anything from the leprosy approach? (2024) Wakerley, D., de Barros, B., Moore, D. A. J., Walker, S. L., Walker, T., and Esmail, H. Lancet Glob Health 12, e1393-e1394: https://doi.org/10.1016/S2214-109X(24)00254-7.

Protective role of Bacillus Calmette-Guerin vaccine in Alzheimer's disease progression: A systematic review and meta-analysis. (2024) Umar, T. P., Jain, N., Stevanny, B., Javed, B., Priandhana, A., Siburian, R., and Kostiks, A. Heliyon 10, e27425: https://doi.org/10.1016/j.heliyon.2024.e27425.

Quantifying non-adherence to anti-tuberculosis treatment due to early discontinuation: a systematic literature review of timings to loss to follow-up. (2024) Walker, E. F., Flook, M., Rodger, A. J., Fielding, K. L., and Stagg, H. R. BMJ Open Respir Res 11https://doi.org/10.1136/bmjresp-2023-001894.

Radiographic characteristics of rifampicin-resistant tuberculosis in the STREAM stage 1 trial and their influence on time to culture conversion in the short regimen. (2024) Chiang, C. Y., Bern, H., Goodall, R., Chien, S. T., Rusen, I. D., Nunn, A., and Collaborators, S. S.-s. BMC Infect Dis 24, 144: https://doi.org/10.1186/s12879-024-09039-z.

Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after eight weeks of anti-tuberculous treatment. (2024) Calderwood, C. J., Sanchez Martinez, A., Greenan-Barrett, J., Turner, C. T., Oguti, B., Roe, J. K., Gupta, R., Martineau, A. R., and Noursadeghi, M. Eur Respir Jhttps://doi.org/10.1183/13993003.00457-2024.

Risk of tuberculosis after initiation of antiretroviral therapy among persons with HIV in Europe. (2024) Johansen, I. S., Roen, A., Kraef, C., Martin-Iguacel, R., Nemeth, J., Fenner, L., Zangerle, R., Llibre, J. M., Miller, R. F., Suarez, I., de Wit, S., Wit, F., Mussini, C., Saracino, A., Canetti, D., Volny-Anne, A., Jaschinski, N., Neesgaard, B., Ryom, L., Peters, L., Garges, H. P., Rooney, J. F., Podlekareva, D., Mocroft, A., Kirk, O., and group, R. S. Int J Infect Dis 147, 107199: https://doi.org/10.1016/j.ijid.2024.107199.

Screening for latent tuberculosis in migrants-status quo and future challenges. (2024) Petersen, E., Al-Abri, S., Al-Jardani, A., Memish, Z. A., Aklillu, E., Ntoumi, F., Mwaba, P., Wejse, C., Zumla, A., and Al-Yaquobi, F. Int J Infect Dis 141S, 107002: https://doi.org/10.1016/j.ijid.2024.107002.

Screening for tuberculosis infection and effectiveness of preventive treatment among people with HIV in low-incidence settings. (2024) van Geuns, D., Arts, R. J. W., de Vries, G., Wit, F., Degtyareva, S. Y., Brown, J., Pareek, M., Lipman, M., and van Crevel, R. AIDS 38, 193-205: https://doi.org/10.1097/QAD.0000000000003747.

Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study. (2024) Olbrich, L., Franckling-Smith, Z., Larsson, L., Sabi, I., Ntinginya, N. E., Khosa, C., Banze, D., Nliwasa, M., Corbett, E. L., Semphere, R., Verghese, V. P., Michael, J. S., Ninan, M. M., Saathoff, E., McHugh, T. D., Razid, A., Graham, S. M., Song, R., Nabeta, P., Trollip, A., Nicol, M. P., Hoelscher, M., Geldmacher, C., Heinrich, N., Zar, H. J., and RaPaed, A.-T. B. c. Lancet Infect Dis https://doi.org/10.1016/S1473-3099(24)00494-8.

Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial. (2024) Nyang'wa, B. T., Berry, C., Kazounis, E., Motta, I., Parpieva, N., Tigay, Z., Moodliar, R., Dodd, M., Solodovnikova, V., Liverko, I., Rajaram, S., Rassool, M., McHugh, T., Spigelman, M., Moore, D. A., Ritmeijer, K., du Cros, P., Fielding, K., and team, T.-P. Lancet Respir Med 12, 117-128: https://doi.org/10.1016/S2213-2600(23)00389-2.

Subclinical tuberculosis linkage to care and completion of treatment following community-based screening in rural South Africa. (2024) Sifumba, Z., Claassen, H., Olivier, S., Khan, P., Ngubane, H., Bhengu, T., Zulu, T., Sithole, M., Gareta, D., Vukuzazi, T., Moosa, M. S., Hanekom, W. A., Bassett, I. V., and Wong, E. B. BMC Glob Public Health 2, 30: https://doi.org/10.1186/s44263-024-00059-0.

Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis. (2024) Shao, Z., Tam, K. K., Achalla, V. P. K., Woon, E. C. Y., Mason, A. J., Chow, S. F., Yam, W. C., and Lam, J. K. W. Int J Pharm 654, 123960: https://doi.org/10.1016/j.ijpharm.2024.123960.

Systematic review and meta-analysis of tuberculosis and COVID-19 co-infection: Prevalence, fatality, and treatment considerations. (2024) Wang, Q., Cao, Y., Liu, X., Fu, Y., Zhang, J., Zhang, Y., Zhang, L., Wei, X., and Yang, L. PLoS Negl Trop Dis 18, e0012136: https://doi.org/10.1371/journal.pntd.0012136.

Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions? (2024) Hamada, Y., Quartagno, M., Law, I., Malik, F., Bonsu, F. A., Adetifa, I. M. O., Adusi-Poku, Y., D'Alessandro, U., Bashorun, A. O., Begum, V., Lolong, D. B., Boldoo, T., Dlamini, T., Donkor, S., Dwihardiani, B., Egwaga, S., Farid, M. N., Garfin, A., Gaviola, D. M. G., Husain, M. M., Ismail, F., Kaggwa, M., Kamara, D. V., Kasozi, S., Kaswaswa, K., Kirenga, B., Klinkenberg, E., Kondo, Z., Lawanson, A., Macheque, D., Manhica, I., Maama-Maime, L. B., Mfinanga, S., Moyo, S., Mpunga, J., Mthiyane, T., Mustikawati, D. E., Mvusi, L., Nguyen, H. B., Nguyen, H. V., Pangaribuan, L., Patrobas, P., Rahman, M., Rahman, M., Rahman, M. S., Raleting, T., Riono, P., Ruswa, N., Rutebemberwa, E., Rwabinumi, M. F., Senkoro, M., Sharif, A. R., Sikhondze, W., Sismanidis, C., Sovd, T., Stavia, T., Sultana, S., Suriani, O., Thomas, A. M., Tobing, K., Van der Walt, M., Walusimbi, S., Zaman, M. M., Floyd, K., Copas, A., Abubakar, I., and Rangaka, M. X. PLOS Glob Public Health 4, e0002596: https://doi.org/10.1371/journal.pgph.0002596.

The treatment of latent tuberculosis infection in migrants in primary care versus secondary care. (2024) Burman, M., Zenner, D., Copas, A. J., Gosce, L., Haghparast-Bidgoli, H., White, P. J., Hickson, V., Greyson, O., Trathen, D., Ashcroft, R., Martineau, A. R., Abubakar, I., Griffiths, C. J., and Kunst, H. Eur Respir J https://doi.org/10.1183/13993003.01733-2023.

Treatment preferences among people at risk of developing tuberculosis: A discrete choice experiment. (2024) Kamchedzera, W., Quaife, M., Msukwa-Panje, W., Burke, R. M., Macpherson, L., Kumwenda, M., Twabi, H. H., Quartagno, M., MacPherson, P., and Esmail, H. PLOS Glob Public Health 4, e0002804: https://doi.org/10.1371/journal.pgph.0002804.

Tribbles1 is host protective during in vivo mycobacterial infection. (2024) Hammond, F. R., Lewis, A., Pollara, G., Tomlinson, G. S., Noursadeghi, M., Kiss-Toth, E., and Elks, P. M. Elife 13 https://doi.org/10.7554/eLife.95980.

Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study. (2024) Rodriguez-Molino, P., Tebruegge, M., Noguera-Julian, A., Neth, O., Fidler, K., Brinkmann, F., Sainz, T., Ivaskeviciene, I., Ritz, N., Brito, M. J., Milheiro Silva, T., Chechenieva, V., Serdiuk, M., Lancella, L., Russo, C., Soler-Garcia, A., Navarro, M. L., Krueger, R., Feiterna-Sperling, C., Starshinova, A., Hiteva, A., Hoffmann, A., Kalibatas, P., Lo Vecchio, A., Scarano, S. M., Bustillo, M., Blazquez Gamero, D., Espiau, M., Buonsenso, D., Falcon, L., Turnbull, L., Colino, E., Rueda, S., Buxbaum, C., Carazo, B., Alvarez, C., Dapena, M., Piqueras, A., Velizarova, S., Ozere, I., Gotzinger, F., Pareja, M., Garrote Llanos, M. I., Soto, B., Rodriguez Martin, S., Korta, J. J., Perez-Gorricho, B., Herranz, M., Hernandez-Bartolome, A., Diaz-Almiron, M., Kohns Vasconcelos, M., Ferreras-Antolin, L., and Santiago-Garcia, B. Clin Infect Dis https://doi.org/10.1093/cid/ciae158.

Tuberculin skin test surveys and the Annual Risk of Tuberculous Infection in school children in Northern KwaZulu-Natal. (2024) Yates, T. A., Cebekhulu, S., Mthethwa, M., Fourie, P. B., Newell, M. L., Abubakar, I., and Tanser, F. PLOS Glob Public Health 4, e0003263: https://doi.org/10.1371/journal.pgph.0003263.

Tuberculosis prevention: current strategies and future directions. (2024) Vasiliu, A., Martinez, L., Gupta, R. K., Hamada, Y., Ness, T., Kay, A., Bonnet, M., Sester, M., Kaufmann, S. H. E., Lange, C., and Mandalakas, A. M. Clin Microbiol Infect 30, 1123-1130: https://doi.org/10.1016/j.cmi.2023.10.023.

Tuberculosis treatment monitoring tests during routine practice: study design guidance. (2024) MacLean, E. L., Zimmer, A. J., den Boon, S., Gupta-Wright, A., Cirillo, D. M., Cobelens, F., Gillespie, S. H., Nahid, P., Phillips, P. P., Ruhwald, M., and Denkinger, C. M. Clin Microbiol Infect https://doi.org/10.1016/j.cmi.2023.12.027.

Tuberculosis-associated hemophagocytic lymphohistiocytosis: diagnostic challenges and determinants of outcome. (2024) Kurver, L., Seers, T., van Dorp, S., van Crevel, R., Pollara, G., and van Laarhoven, A. Open Forum Infect Dis 11, ofad697: https://doi.org/10.1093/ofid/ofad697.

T-wave morphology abnormalities in the STREAM stage 1 trial. (2024) Hughes, G., Young, W. J., Bern, H., Crook, A., Lambiase, P. D., Goodall, R. L., Nunn, A. J., and Meredith, S. K. Expert Opin Drug Saf 23, 469-476: https://doi.org/10.1080/14740338.2024.2322116.

Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea: A systematic review of WGS use on human pathogens in individual patient care. (2024) Osman, R., Dema, E., David, A., Hughes, G., Field, N., Cole, M., Didelot, X., and Saunders, J. J Infect 88, 106168: https://doi.org/10.1016/j.jinf.2024.106168.

Variability in plasma rifampicin concentrations and role of SLCO1B1, ABCB1, AADAC2 and CES2 genotypes in Ethiopian patients with tuberculosis. (2024) Sileshi, T., Makonnen, E., Telele, N. F., Barclay, V., Zumla, A., and Aklillu, E. Infect Dis (Lond), 1-12: https://doi.org/10.1080/23744235.2024.2309348.

What is next for BCG revaccination to prevent tuberculosis? (2024) White, R. G., Fiore-Gartland, A. J., Hanekom, W. A., Vekemans, J., Garcia-Basteiro, A. L., Churchyard, G., Rangaka, M. X., Frick, M., Behr, M. A., Hill, P. C., and Mave, V. Lancet Respir Med https://doi.org/10.1016/S2213-2600(24)00009-2.

World Tuberculosis Day 2024 theme "Yes! We can end TB" can be made a reality through concerted global efforts that advance detection, diagnosis, and treatment of tuberculosis infection and disease. (2024) Goletti, D., Al-Abri, S., Migliori, G. B., Arlehamn, C. L., Haldar, P., Sundling, C., da Costa, C., To, K. W., Martineau, A. R., Petersen, E., Zumla, A., and Shan Lee, S. Int J Infect Dis 141S, 106993: https://doi.org/10.1016/j.ijid.2024.106993.

Other Outputs

Blog: UKAPTB meeting: Strengthening partnerships across the UK to end TB. Jess Potter.

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