Research Publications
Number of publications: 120.
2018
- Blyuss, O., Burnell, M., Ryan, A., Gentry-Maharaj, A., Marino, I., Kalsi, J., ...Skates, S. (2018). Comparison of longitudinal CA125 algorithms as a first line screen for ovarian cancer in the general population. Clinical Cancer Research, doi:10.1158/1078-0432.CCR-18-0208
- Wolhuter, K., Whitwell, H.J., Switzer, C.H., Burgoyne, J.R., Timms, J.F., Eaton, P. (2018). Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Molecular Cell, 69 (3), 438-+. doi:10.1016/j.molcel.2017.12.019
- Mariño, I.P., Blyuss, O., Ryan, A., Gentry-Maharaj, A., Timms, J.F., Dawnay, A., ...Zaikin, A. (2018). How detecting change-points in biomarkers time series can support the diagnostic approaches of ovarian cancer.
- Cuenco, J., Wehnert, N., Blyuss, O., Kazarian, A., Whitwell, H.J., Menon, U., ...Timms, J.F. (2018). Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis.Oncotarget, 9 (25), 17430-17442. doi:10.18632/oncotarget.24732
- Whitwell, H.J., Blyuss, O., Menon, U., Timms, J.F., Zaikin, A. (2018). Parenclitic networks for predicting ovarian cancer. Oncotarget, 9 (32), 22717-22726. doi:10.18632/oncotarget.25216
2017
- Worthington, J., Spain, G., Timms, J.F. (2017). Effects of ErbB2 overexpression on the proteome and ErbB ligand-specific phosphosignalling in mammary luminal epithelial cells.. Mol Cell Proteomics, doi:10.1074/mcp.M116.061267
- Spencer, R., Ambler, G., Brodszki, J., Diemert, A., Figueras, F., Gratacós, E., ...Marlow, N. (2017). EVERREST prospective study: a 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction.. BMC Pregnancy Childbirth, 17 (1), 43. doi:10.1186/s12884-017-1226-7
- Krishnan, S., Whitwell, H.J., Cuenco, J., Gentry-Maharaj, A., Menon, U., Pereira, S.P., ...Timms, J.F. (2017). Evidence of Altered Glycosylation of Serum Proteins Prior to Pancreatic Cancer Diagnosis.. International journal of molecular sciences, 18 (12), doi:10.3390/ijms18122670
- Eberhardt, C., Thillai, M., Parker, R., Siddiqui, N., Potiphar, L., Goldin, R., ...Wickremasinghe, M. (2017). Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis.. PLoS One, 12 (1), e0170285. doi:10.1371/journal.pone.0170285
- Irungu, S., Mavrelos, D., Worthington, J., Blyuss, O., Saridogan, E., Timms, J. (2017). Searching for endometriosis biomarkers with proteomics.
- Kazarian, A., Blyuss, O., Metodieva, G., Gentry-Maharaj, A., Ryan, A., Kiseleva, E.M., ...Menon, U. (2017). Testing breast cancer serum biomarkers for early detection and prognosis in pre-diagnosis samples.. British Journal of Cancer, doi:10.1038/bjc.2016.433
2016
- Timms, J.F., Hale, O.J., Cramer, R. (2016). Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics. Expert Review of Proteomics, 13 (6), 593-607. doi:10.1080/14789450.2016.1182431
- Mariño, I.P., Blyuss, O., Ryan, A., Gentry-Maharaj, A., Timms, J.F., Dawnay, A., ...Zaikin, A. (2016). Change-point of multiple biomarkers in women with ovarian cancer. Biomedical Signal Processing and Control, 33 169-177. doi:10.1016/j.bspc.2016.11.015
- Scotcher, J., Prysyazhna, O., Boguslavskyi, A., Kistamas, K., Hadgraft, N., Martin, E.D., ...Cuello, F. (2016). Disulfide-activated protein kinase G I alpha regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.NATURE COMMUNICATIONS, 7 doi:10.1038/ncomms13187
- Prysyazhna, O., Scotcher, J., Boguslavskyi, A., Kistamas, K., Hadgraft, N., Martin, E.D., ...Cuello, F. (2016). Redox Control of Protein Kinase G I alpha Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation.
- Thawer, S., Auret, J., Schnoeller, C., Chetty, A., Smith, K., Darby, M., ...Timms, J.F. (2016). Surfactant Protein-D Is Essential for Immunity to Helminth Infection. PLOS PATHOGENS, 12 (2), doi:10.1371/journal.ppat.1005461
2015
- Jenkinson, C., Elliott, V.L., Evans, A., Oldfield, L., Jenkins, R.E., O'brien, D.P., ...Jacobs, I.J. (2015). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: Association with diabetes mellitus. Clinical Cancer Research, 22 (7), 1734-1743. doi:10.1158/1078-0432.CCR-15-0879
- Jenkinson, C., Elliott, V.L., Evans, A., Oldfield, L., Timms, J.F., Gentry-Maharaj, A., ...Sutton, R. (2015). Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development?.
- Camuzeaux, S., Timms, J.F. (2015). Disease profiling by MALDI MS analysis of biofluids. In Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. (pp. 185-196). .
- Jenkinson, C., Elliott, V., Menon, U., Apostolidou, S., Fourkala, O.E., Gentry-Maharaj, A., ...Greenhalf, W. (2015). Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer.. JOURNAL OF PROTEOMICS, 113 400-402. doi:10.1016/j.jprot.2014.10.001
- Thomas, D.S., Fourkala, E.-.O., Apostolidou, S., Gunu, R., Ryan, A., Jacobs, I., ...Timms, J.F. (2015). Evaluation of CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical serum samples.. British Journal of Cancer, doi:10.1038/bjc.2015.202
- Lawrenson, K., Mhawech-Fauceglia, P., Worthington, J., Spindler, T.J., O'Brien, D., Lee, J.M., ...Darcy, K.M. (2015). Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis. INTERNATIONAL JOURNAL OF CANCER, 137 (8), 1806-1817. doi:10.1002/ijc.29197
- Nouretdinov, I., Devetyarov, D., Vovk, V., Burford, B., Luo, Z., Chervonenkis, A., ...Hallett, R. (2015). Multiprobabilistic prediction in early medical diagnoses. ANNALS OF MATHEMATICS AND ARTIFICIAL INTELLIGENCE, 74 (1-2), 203-222. doi:10.1007/s10472-013-9367-5
- Blyuss, O., Gentry-Maharaj, A., Fourkala, E.-.O., Ryan, A., Zaikin, A., Menon, U., ...Timms, J.F. (2015). Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset. BIOMED RESEARCH INTERNATIONAL, doi:10.1155/2015/681416
- O'Brien, D.P., Sandanayake, N.S., Jenkinson, C., Gentry-Maharaj, A., Apostolidou, S., Fourkala, E.-.O., ...Dawnay, A. (2015). Serum CA19-9 is significantly upregulated up to 2 years before diagnosis with pancreatic cancer: implications for early disease detection.. CLINICAL CANCER RESEARCH, 21 (3), 622-631. doi:10.1158/1078-0432.CCR-14-0365
- Gonzalez Malagon, S.G., Melidoni, A.N., Hernandez, D., Omar, B.A., Veeravalli, S., Houseman, L., ...Tsuchiya, Y. (2015). The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochemical Pharmacology, doi:10.1016/j.bcp.2015.05.013
2014
- Fry, S.A., Sinclair, J., Timms, J.F., Leathem, A.J., Dwek, M.V. (2014). A targeted glycoproteomic approach for the identification of a novel biomarker of metastatic breast cancer.
- Timms, J.F., Arslan-Low, E., Kabir, M., Worthington, J., Camuzeaux, S., Sinclair, J., ...Fourkala, E.-.O. (2014). Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies.. PROTEOMICS CLINICAL APPLICATIONS, 8 (11-12), 982-993. doi:10.1002/prca.201400063
- O'Brien, D.P., Timms, J.F. (2014). Employing TMT quantification in a shotgun-MS platform.. In Martins-de-Souza, D. (Ed.), Shotgun Proteomics: Methods and Protocols. (pp. 187-199). Springer.
- Sandanayake, N.S., Camuzeaux, S., Sinclair, J., Blyuss, O., Andreola, F., Chapman, M.H., ...Pereira, S.P. (2014). Identification of potential serum peptide biomarkers of biliary tract cancer using MALDI MS profiling.. Journal of Proteomics, doi:10.1186/1472-6890-14-7
- Tiss, A., Timms, J.F., Menon, U., Gammerman, A., Cramer, R. (2014). Proteomics approaches towards early detection and diagnosis of ovarian cancer.
- Thillai, M., Eberhardt, C., Timms, J., Goldin, R., Ellis, R., Mitchell, D., ...Lalvani, A. (2014). Quantitative Proteomics Identifies A Decreased Expression Of Proteins Involved With Immune Cell Receptor Signaling And Cytotoxicity In Sarcoidosis.
- Wulandari, R., Menon, U., Pereira, S.P., Timms, J.F. (2014). Testing AGR2 as an early cancer biomarker.
2013
- Alderton, W., Apostolidou, S., Fisher, M., Flynn, A., Gentry-Maharaj, A., Hodkinson, C., ...Sandanayake, N. (2013). CA19.9 profile in samples pre-dating pancreatic cancer diagnosis - nested case control study in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).
- Zheng, D., Worthington, J., Timms, J.F., Woo, P. (2013). HNRNPA1 interacts with a 5′-flanking distal element of interleukin-6 and upregulates its basal transcription. Genes and Immunity, doi:10.1038/gene.2013.41
- Jenkinson, C., Elliott, V., O'Brien, D., Evans, A., Sutton, R., Lane, B., ...Jacobs, I. (2013). iTRAQ Reveals a Serum Marker Significantly Altered in Patients up to 24 Months Prior to Diagnosis With Pancreatic Cancer.
- Skipworth, J.R.A., Timms, J.F., Pereira, S.P. (2013). Novel diagnostic and prognostic biomarkers in biliary tract cancer.. Expert Opinion on Medical Diagnostics, 7 (5), 487-499.
- Sinclair, J., Timms, J.F. (2013). Proteomic profiling of ovarian cancer models using TMT-LC-MS/MS. In Malek, A., Tchernitsa, O. (Eds.), Ovarian Cancer - Methods and Protocols. Humana Press.
2012
- Fry, S.A., Sinclair, J., Timms, J.F., Leathem, A.J., Dwek, M.V. (2012). A targeted glycoproteomic approach identifies cadherin-5 as a novel biomarker of metastatic breast cancer. Cancer Letters, 328 (2), 335-344. doi:10.1016/j.canlet.2012.10.011
- Devetyarov, D., Nouretdinov, I., Burford, B., Camuzeaux, S., Gentry-Maharaj, A., Tiss, A., ...Hallett, R. (2012). Conformal predictors in early diagnostics of ovarian and breast cancers. Progress in Artificial Intelligence,
- Nagano, K., Akpan, A., Warnasuriya, G., Yang, A., Stein, R., Zvelebil, M., ...Burlinghame, A. (2012). Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase co-activation in Swiss 3T3 fibroblasts. Molecular and Cellular Proteomics, doi:10.1074/mcp.M112.019778
- Chen, Y.-.W., Lu, Y.-.C., Chen, Y.-.H., Chou, H.-.C., Timms, J.F., Lee, Y.-.R., Chan, H.-.L. (2012). Hemopexin is up-regulated in plasma from type 1 diabetes mellitus patients: role of glucose-induced ROS. Journal of Proteomics, 75 (12), 3760-3777. doi:10.1016/j.jprot.2012.04.047
- Nouretdinov, I., Devetyarov, D., Burford, B., Camuzeaux, S., Gentry-Maharaj, A., Tiss, A., ...Hallett, R. (2012). Multiprobabilistic Venn predictors with logistic regression. In Artificial intelligence applications and innovations. (pp. 224-233). Berlin, Germany: Springer.
- Chan, H.L., Sinclair, J., Timms, J.F. (2012). Proteomic analysis of redox-dependent changes using cysteine-labeling 2D DIGE. In (pp. 113-128). .
- Chan, H.-.L., Sinclair, J., Timms, J.F. (2012). Proteomic analysis of redox-dependent changes using cysteine-labeling two-dimensional difference gel electrophoresis.. In Cramer, R., Westermeier, R. (Eds.), Difference gel electrophoresis (DIGE). (pp. 113-128). Humana Press.
- Chou, H.C., Lu, Y.C., Cheng, C.S., Chen, Y.W., Lyu, P.C., Lin, C.W., ...Chan, H.L. (2012). Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells. Journal of Proteomics, 75 (11), 3158-3176. doi:10.1016/j.jprot.2012.03.010
2011
- Sandanayake, N.S., Sinclair, J., Andreola, F., Chapman, M.H., Xue, A., Webster, G.J., ...Smith, R.C. (2011). A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures.. BRITISH JOURNAL OF CANCER, 105 (9), 1370-1378. doi:10.1038/bjc.2011.376
- Dumartin, L., Whiteman, H.J., Weeks, M.E., Hariharan, D., Dmitrovic, B., Iacobuzio-Donahue, C.A., ...Timms, J.F. (2011). AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.. CANCER RESEARCH, 71 (22), 7091-7102. doi:10.1158/0008-5472.CAN-11-1367
- Jenkinson, C., Elliott, V., Jenkins, R., Menon, U., Gentry-Maharaj, A., Pereira, S., ...Costello, E. (2011). Development of Multiple Reaction Monitoring techniques for the quantification of biomarkers of pancreatic cancer.
- Timms, J.F., Menon, U., Devetyarov, D., Tiss, A., Camuzeaux, S., McCurrie, K., ...Gentry-Maharaj, A. (2011). Early detection of ovarian cancer in samples pre-diagnosis using CA125 and MALDI-MS peaks.. Cancer Genomics Proteomics, 8 (6), 289-305.
- Díez-Dacal, B., Gayarre, J., Gharbi, S., Timms, J.F., Coderch, C., Gago, F., Pérez-Sala, D. (2011). Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by PGA1. Implications for antitumoral activity. Cancer Research, 71 (12), 4161-4171. doi:10.1158/0008-5472.CAN-10-3816
- Worthington, J., Cutillas, P.R., Timms, J.F. (2011). IMAC/TiO(2) enrich for peptide modifications other than phosphorylation: implications for chromatographic choice and database searching in phosphoproteomics..PROTEOMICS, 11 (23), 4583-4587. doi:10.1002/pmic.201100143
- Fry, S.A., Afrough, B., Lomax-Browne, H.J., Timms, J.F., Velentzis, L.S., Leathem, A.J.C. (2011). Lectin microarray profiling of metastatic breast cancer glycans. Glycobiology, 21 (8), 1060-1070. doi:10.1093/glycob/cwr045
- Sinclair, J., Metodieva, G., Dafou, D., Gayther, S., Timms, J.F. (2011). Profiling signatures of ovarian cancer tumour suppression using 2D-DIGE and 2D-LC-MS/MS with tandem mass tagging. J Proteomics, 74 (4), 451-465. doi:10.1016/j.jprot.2010.12.009
- Navaratnarajah, R., Sinclair, J., Grun, B., Timms, J.F., Hardiman, P.J. (2011). Proteome investigation in the pcos endometrium associated with obesity.
- Sinclair, J., Timms, J.F. (2011). Quantitative profiling of serum samples using TMT protein labelling, fractionation and LC-MS/MS.. Methods, 54 (4), 361-369. doi:10.1016/j.ymeth.2011.03.004
2010
- Garzón, B., Gayarre, J., Gharbi, S., Díez-Dacal, B., Sánchez-Gómez, F.J., Timms, J.F., Pérez-Sala, D. (2010). A biotinylated analog of the anti-proliferative prostaglandin A(1) allows assessment of PPAR-independent effects and identification of novel cellular targets for covalent modification. Chemical and Biological Interactions, 183 (1), 212-221. doi:10.1016/j.cbi.2009.09.019
- Tiss, A., Smith, C., Menon, U., Jacobs, I., Timms, J.F., Cramer, R. (2010). A well-characterised peak identification list of MALDI MS profile peaks for human blood serum.. Proteomics, 10 (18), 3388-3392. doi:10.1002/pmic.201000100
- Dumartin, L., Whiteman, H.J., Weeks, M.E., Timms, J.F., Brentnall, T.A., Bronner, M.P., ...Crnogorac-Jurcevic, T. (2010). AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D.
- Navaratnarajah, R., Grun, B., Sinclair, J., Dafou, D., Gayther, S., Timms, J.F., Hardiman, P.J. (2010). Apoptotic and cell cycle proteome investigation in the pcos endometrium associated with obesity.
- Cutillas, P.R., Timms, J.F. (2010). Approaches and applications of quantitative LC-MS for proteomics and activitomics.In Timms, J.F., Cutillas, P.R. (Eds.), LC-MS in Proteomics. (pp. 3-17). Humana Press.
- Sandanayake, N.S., Sinclair, J., Andreola, F., Chapman, M.H., Camuzeaux, S., Webster, G.J., ...Pereira, S.P. (2010). Characterisation of serum proteins in biliary tract cancer, primary sclerosing cholangitis and immunoglobulin G4-associated cholangitis using 2-dimensional difference gel electrophoresis and tandem mass spectrometry.
- Tiss, A., Timms, J.F., Smith, C., Devetyarov, D., Gentry-Maharaj, A., Camuzeaux, S., ...Luo, Z.Y. (2010). Highly Accurate Detection of Ovarian Cancer Using CA125 but Limited Improvement With Serum Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Profiling. INT J GYNECOL CANCER, 20 (9), 1518-1524. doi:10.1111/IGC.0b013e3181fc1990
- Timms, J.F., Cutillas, P.R. (Eds.), (2010). LC-MS in proteomics. Humana Press.
- Chan, H.-.L., Chou, H.-.C., Duran, M., Gruenewald, J., Waterfield, M.D., Ridley, A., Timms, J.F. (2010). Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells.. J Biol Chem, 285 (7), 4307-4318. doi:10.1074/jbc.M109.047027
- Eddaoudi, A., Townsend-Nicholson, A., Timms, J.F., Schorge, S., Jayasinghe, S.N. (2010). Molecular characterisation of post-bio-electrosprayed human brain astrocytoma cells. Analyst, 135 (10), 2600-2612. doi:10.1039/C0AN00213E
- Timms, J.F., Cutillas, P.R. (2010). Overview of quantitative LC-MS techniques for proteomics and activitomics.. In Timms, J.F., Cutillas, P.R. (Eds.), LC-MS in Proteomics. (pp. 19-45). Humana Press.
- Timms, J.F., Cramer, R., Camuzeaux, S., Tiss, A., Smith, C., Burford, B., ...Ford, J. (2010). Peptides generated ex vivo from serum proteins by tumor-specific exopeptidases are not useful biomarkers in ovarian cancer. CLINICAL CHEMISTRY, 56 {262-271}. doi:10.1373/clinchem.2009.133363
- Chou, H.-.C., Chen, Y.-.W., Lee, T.-.R., Wu, F.-.S., Chan, H.-.T., Lyu, P.-.C., ...Chan, H.-.L. (2010). Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia reperfusion injury and treatment. Free Radical Biology and Medicine, 49 (1), 96-108. doi:10.1016/j.freeradbiomed.2010.04.001
- Sandanayake, N.S., Andreola, F., Camuzeaux, S., Sinclair, J., Chapman, M.H., Webster, G.J., ...Smith, R.C. (2010). SERUM CEACAM1 IN THE PRECLINICAL DIAGNOSIS OF PANCREATIC ADENOCARCINOMA.
- Worthington, J., Bertani, M., Chan, H.-.L., Gerrits, B., Timms, J.F. (2010). Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation. BMC Cancer, 10 doi:10.1186/1471-2407-10-490
2009
- George, R., Chan, H.-.L., Ahmed, Z., Suen, K.M., Stevens, C.N., Levitt, J.A., ...Ladbury, J.E. (2009). A complex of Shc and Ran-GTPase localises to the cell nucleus. Cellular and Molecular Life Sciences, 66 (4), 711-720. doi:10.1007/s00018-009-8667-8
- Duran, M.C., Chan, H.-.L., Timms, J.F. (2009). Identification of oxidative stress-induced tyrosine phosphorylated proteins by immunoprecipitation and mass spectrometry.. In Graauw, M.D. (Ed.), Phosphoproteomics: methods and protocols. (pp. 33-45). Humana Press.
- Gammerman, A., Vovk, V., Burford, B., Nouretdinov, I., Luo, Z., Chervonenkis, A., ...Villanueva, J. (2009). Serum proteomic abnormality predating screen detection of ovarian cancer. The Computer Journal, 52 326-333. doi:10.1093/comjnl/bxn021
- Grun, B., Benjamin, E., Sinclair, J., Timms, J.F., Jacobs, I.J., Gayther, S.A., Dafou, D. (2009). Three-dimensional in vitro cell biology models of ovarian and endometrial cancer. Cell Proliferation, 42 (2), 219-228. doi:10.1111/j.1365-2184.2008.00579.x
2008
- Weeks, M.E., Hariharan, D., Petronijevic, L., Radon, T.P., Whiteman, H.J., Kocher, H., ...Crnogorac-Jurcevic, T. (2008). Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma. Proteomics: Clinical Applications, 2 (7-8), 1047-1057.
- Timms, J.F. (2008). Book Review: Cancer Proteomics from Bench to Bedside (edited by Sayed S. Daoud, Humana Press, ISBN 978-1-58829-858-4). British Journal of Cancer, 99 679. doi:10.1038/sj.bjc.6604537
- Duran, M., Vega, F., Moreno-Bueno, G., Artiga, M., Sanchez, L., Palacios, J., ...Timms, J.F. (2008). Characterisation of tumoral markers correlated with ErbB2 (HER2/Neu) overexpression and metastasis in breast cancer. Proteomics: Clinical Applications, 2 (9), 1313-1326. doi:10.1002/prca.200780020
- Timms, J.F., Cramer, R. (2008). Difference gel electrophoresis.. Proteomics, 8 (23-24), 4886-4897. doi:10.1002/pmic.200800298
- Timms, J.F. (2008). Editorial overview: Protein technologies. Curr Opin Biotech, 19 (4), 313-315. doi:10.1016/j.copbio.2008.07.003
- Huang, H.-.L., Cendan, C.-.M., Roza, C., Okuse, K., Cramer, R., Timms, J.F., Wood, J.N. (2008). Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves.Molecular Pain, 4 (33),
2007
- Jovceva, E., Larsen, M.R., Waterfield, M.D., Baum, B., Timms, J.F. (2007). Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis. Journal of Cell Science, 120 (11), 1888-1897. doi:10.1242/jcs.004366
- Gharbi, S.I., Zvelebil, M.J., Shuttleworth, S.J., Hancox, T., Saghir, N., Timms, J.F., Waterfield, M.D. (2007). Exploring the specificity of the PI3K family inhibitor LY294002. Biochemical Journal, 404 (1), 15-21. doi:10.1042/BJ20061489
- Timms, J.F. (2007). Gel electrophoresis, 2D-difference.. In Meyers, R.A. (Ed.), Proteins::From Analytics to Structural Genomics. (pp. 647-665). Wiley-VCH.
- Stehle Jr, J.R., Weeks, M.E., Lin, K., Willingham, M.C., Hicks, A.M., Timms, J.F., Cui, Z. (2007). Mass spectrometry identification of circulating alpha-1-B glycoprotein, increased in aged female C57BL/6 mice1. Biochim.Biophys.Acta, 1770 (1), 79-86.
- Timms, J.F., Arslan-Low, E., Gentry-Maharaj, A., Luo, Z., T'Jampens, D., Podust, V.N., ...Jacobs, I.J. (2007). Preanalytic influence of sample handling on SELDI-TOF serum protein profiles. Clin Chem., 43 (4), 645-656. doi:10.1373/clinchem.2006.080101
- Tiss, A., Smith, C., Camuzeaux, S., Kabir, M., Gayther, S., Menon, U., ...Cramer, R. (2007). Serum peptide profiling using MALDI mass spectrometry: avoiding the pitfalls of coated magnetic beads using well-established ZipTip technology. Proteomics, 7 (suppl 1), 77-89. doi:10.1002/pmic.200700746
- Gharbi, S., Garzon, B., Gayarre, J., Timms, J., Perez-Sala, D. (2007). Study of protein targets for covalent modification by the antitumoral and anti-inflammatory prostaglandin PGA(1): focus on vimentin1. J.Mass Spectrom., 42 (11), 1474-1484. doi:10.1002/jms.1291
- Whiteman, H.J., Weeks, M.E., Dowen, S.E., Barr, S., Timms, J.F., Lemoine, N.R., Crnogorac-Jurcevic, T. (2007). The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D. Cancer Research, 67 8633-8642. doi:10.1158/0008-5472.CAN-07-0545
2006
- Weeks, M.E., Sinclair, J., Butt, A., Chung, Y.L., Worthington, J.L., Wilkinson, C.R., ...Timms, J.F. (2006). A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe. Proteomics, 6 (9), 2772-2796. doi:10.1002/pmic.200500741
- T’Jampens, D., Arslan-Low, E., Timms, J.F., Gentry-Maharaj, A., Ford, J., Gammerman, A., ...Jacobs, I.J. (2006). Evaluation of pre-analytic influence of sample collection/handling methodologies on the serum proteome is key in biomarker discovery and assay development.
- Chan, H.L., Gaffney, P.R., Waterfield, M.D., Anderle, H., Peter, M.H., Schwarz, H.P., ...Timms, J.F. (2006). Proteomic analysis of UVC irradiation-induced damage of plasma proteins: Serum amyloid P component as a major target of photolysis. FEBS LETT, 580 (13), 3229-3236.
- Sinclair, J., Weeks, M.E., Butt, A., Worthington, J.L., Akpan, A., Jones, N., ...Timms, J. (2006). Proteomic response of Schizosaccharomyces pombe to static and oscillating electromagnetic fields. Proteomics, 6 (17), 4755-4764. doi:10.1002/pmic.200500861
- Timms, J.F. (2006). Two-Dimensional Difference Gel Electrophoresis: Application for the Analysis of Differential Protein Expression in Multiple Biological Samples. In Cell Biology, Four-Volume Set. (pp. 189-196). .
2005
- Timms, J.F. (2005). 2D-Difference gel electrophoresis: Application for the analysis of differential protein expression in multiple biological samples.. In Celis, J.E. (Ed.), Cell Biology: A Laboratory Handbook. Academic Press, Elsevier.
- de Graauw, M., Tijdens, I., Cramer, R., Corless, S., Timms, J.F., van de Water, B. (2005). Heat shock protein 27 is the major differentially phosphorylated protein Involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis. Journal of Biological Chemistry, 280 (33), 29885-29898. doi:10.1074/jbc.M412708200
- Gharbi, S., Shuttleworth, S., Timms, J., Waterfield, M. (2005). Investigation of the specificity of the LY294002 inhibitor for PI3KS and other novel targets using chemical proteomics.
- Gharbi, S., Shuttleworth, S., Timms, J.F., Waterfield, M.D. (2005). Investigation of the specificity of the LY294002 inhibitor for PI3Ks and other novel targets using chemical proteomics.
- Duran, M., Sinclair, J., Palacios, J., Ridley, A., Timms, J.F. (2005). Proteomic analysis of human breast cancer tissues by 2D-DIGE: Characterization of proteins associated with ErbB2 overexpression.
- Chan, H.L., Gharbi, S., Gaffney, P.R., Cramer, R., Waterfield, M.D., Timms, J.F. (2005). Proteomic analysis of redox- and ErbB2-dependent changes in mammary luminal epithelial cells using cysteine- and lysine-labelling two-dimensional difference gel electrophoresis. Proteomics, 5 (11), 2908-2929. doi:10.1002/pmic.200401300
- Weeks, M.E., Sinclair, J., Jacob, R.J., Saxton, M.J., Kirby, S., Jones, J., ...Timms, J.F. (2005). Stress-induced changes in the Schizosaccharomyces pombe proteome using two-dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform. Proteomics, 5 (6), 1669-1685. doi:10.1002/pmic.200401241
2004
- White, S.L., Gharbi, S., Bertani, M.F., Chan, H.L., Waterfield, M.D., Timms, J.F. (2004). Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression. British Journal of Cancer, 90 (1), 173-181.
- Timms, J.F. (2004). Differential protein expression analysis using fluorescence two-dimensional difference gel electrophoresis.. In Encyclopedia of Molecular Cell Biology and Molecular Medicine. (pp. 33-51). Wiley-VCH.
2003
- Timms, J.F., Gharbi, S., White, S., Bertani, M., Chan, H.-.L., Waterfield, M. (2003). Analysis of ErbB-2 overexpression in breast cancer using functional proteomics and genomics.
2002
- Waterfield, M.D., Gharbi, S., Gaffney, P., Huang, A., Cramer, R., White, S., ...Timms, J.F. (2002). Differential protein expression analysis using lysine and cysteine modifying Cy dyes.
- Timms, J.F., White, S.L., O'Hare, M.J., Waterfield, M.D. (2002). Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells. Oncogene, 21 (43), 6573-6586. doi:10.1038/sj.onc.1205847
- Gharbi, S., Gaffney, P., Yang, A., Zvelebil, M.J., Cramer, R., Waterfield, M.D., Timms, J.F. (2002). Evaluation of 2D-differential gel electrophoresis for proteomic expression analaysis of a model breast cancer cell system. Molecular and Cellular Proteomics, 1 (2), 91-98. doi:10.1074/mcp.T100007-MCP200
- Warnasuriya, G.D., Nagano, K., Cramer, R., Zvelebil, M., Timms, J.F., Akpan, A., ...Burlinghame, A.L. (2002). Functional proteomic analysis of receptor tyrosine kinase signaling in Swiss 3T3 cells: Identification of novel differentially regulated downstream effectors of phosphoinsitide-3-kinase.
- Gharbi, S., White, S., Bertani, M., Chan, H.-.L., Waterfield, M., Timms, J.F. (2002). Parallel 2D-DIGE and microarray expression profiling of a model breast cancer cell system.
- Gharbi, S., Timms, J., Waterfield, M.D. (2002). The use of 2D-DIGE in the study of ErbB2 receptor overexpressing breast cancer cell lines.
2001
- Katso, R., Okkenhaug, K., Ahmadi, K., White, S., Timms, J., Waterfield, M.D. (2001). Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annual Review of Cell and Developmental Biology, 17 615-675. doi:10.1146/annurev.cellbio.17.1.615
- Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., ...Waterfield, M.D. (2001). Synthesis and Function of 3-Phosphorylated Inositol Lipids. Annual Review of Biochemistry, 70 535-602. doi:10.1146/annurev.biochem.70.1.535
1999
- Oh, E.S., Gu, H., Saxton, T.M., Timms, J.F., Hausdorff, S., Frevert, E.U., ...Thomas, S.M. (1999). Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Molecular and Cellular Biology, 19 (4), 3205-15.
- Timms, J.F., Swanson, K.D., Marie-Cardine, A., Raab, M., Rudd, C.E., Schraven, B., Neel, B.G. (1999). SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Current Biology, 9 (16), 927-30.
1998
- Timms, J.F., Carlberg, K., Gu, H., Chen, H., Kamatkar, S., Nadler, M.J., ...Neel, B.G. (1998). Identification of major binding proteins and substrates for the SH2- containing protein tyrosine phosphatase SHP-1 in macrophages.Molecular and Cellular Biology, 18 (7), 3838-3850.
- Neel, B.G., Gu, H., Chen, B., Timms, J., Kamatkar, S., Griffin, J.D. (1998). Role of SHP-2 in hematopoietic cell signaling.
- Wu, Y., Nadler, M.J., Brennan, L.A., Gish, G.D., Timms, J.F., Fusaki, N., ...Wither, J. (1998). The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1. Current Biology, 8 (18), 1009-17.
1997
- OReilly, A.M., Timms, J.F., Neel, B.G. (1997). Functional domains of SHP2 required for EGF signaling in Xenopus.
1995
- Timms, J.F., Noble, M.E., Gregoriou, M. (1995). An investigation of the role of Glu-842, Glu-844 and His-846 in the function of the cytoplasmic domain of the epidermal growth factor receptor. Biochemical Journal, 308 (1), 219-229.
- Gregoriou, M., Jones, P.F., Timms, J.F., Yang, J.J., Radford, S.E., Rees, A.R. (1995). Physicochemical characterization of the cytoplasmic domain of the epidermal growth factor receptor and evidence for conformational changes associated with its activation by ammonium sulphate. Biochemical Journal, 306 ( Pt 3) 667-678.