FASTA
A number of different LAT isoforms were found as well as LAT homologues
in the animal kingdom.
The different human isoforms are first shown, followed by the amino
acid sequences of the other species.
HUMAN LAT ISOFORMS
There are four different isoforms, although isoform a is the most well
characterised and the most abundant one.
The LAT isoform a has 262 amino acids
Its accession number is NP_055202.1
Access Flat file here
Figure 1. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the full results here)
>isoforma
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGI
QFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPS
SRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPE
PACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDS
AFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPA
ALSSQEAEEVEEEGAPDYENLQELN
The LAT isoform b has 233 amino acids
Its accession number is NP_001014987.1
Access the Flat File here.
Figure 2. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the full results here)
>isoformb
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQ
FKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRD
SDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPS
APALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQEL
HPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
The LAT isoform has 232 amino acids
Its accession number is NP_001014988.1
Access the Flat file here.
Figure 3. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the full results here)
>isoformc
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTS
SDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDL
LPIPSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACE
DADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALST
PGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVN
VSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
The LAT isoform has 269 amino acids
Its accession number is NP_001014989.2
Access the Flat file here.
Figure 4. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the results here)
>isoformd
MEATAASWQVAVPVLGGASRPLGPRGAASLLRAPLQME
EAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTS
SDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDL
LPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEEP
ACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPA
LSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSR
EYVNVSQ
We have found LAT homologues in rat (Rattus norvegicus), mouse (Mus
musculus), cow (Bos taurus).
The LAT homologue has 241 amino acids.
Its accession number is NP_110480
Access the Flat file here.
Figure 5. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the results here)
>[Rattus norvegicus]
MEADALSPVELGLLLLPFVVMLLAALCVRCRELPASY
DSASTESLYPRSILIKPPQITVPRTPATSYPLVTSFP
PLRQPDLLPIPRSPQPLGGSHRMPSSRQNSDDANSVA
SYENQEPARKNVDEDEDEDDYPEGYLVVLPDSSPAAV
PVVSSAPVPSNPDLGDSAFSMESCEDYVNVPESEESA
EASLDGSREYVNVSQDAQPVIRAELASVTSQEVEDEE
EEDVDGEEAPDYENLQELN
The LAT homologue has 242 amino acids
Its accession number is AAC40054.1
Access the Flat file here:
Figure 6. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the results here)
>[Mus musculus]
MEADALSPVGLGLLLLPFLVTLLAALCVRCRELPVS
YDSTSTESLYPRSILIKPPQITVPRTPAVSYPLVTS
FPPLRQPDLLPIPRSPQPLGGSHRMPSSQQNSDDAN
SVASYENQEPACKNVDADEDEDDYPNGYLVVLPDSS
PAAVPVVSSAPVPSNPDLGDSAFSVESCEDYVNVPE
SEESAEASLDGSREYVNVSPEQQPVTRAELASVNSQ
EVEDEGEEEGVDGEEAPDYENLQELN
The LAT sequence has 254 amino acids.
Its accession number is DAA15393.1
Access the Flat file here
Figure 7. Summary of results reported by the Phospho.ELM BLAST
Search and Globular domains/ TM domains and signal peptide detected
in the query sequence by the SMART server (access the results here)
> [Bos taurus]
MEAVSPAVYVLGPLLLPLLAVLLMALCVRCRELP
GSYDTAVSDSLTPSSIMIKLPPTLVPRPSTTPYP
LPSQPDLLPIPRSPQPLGGSHCMASSRQDSDSAN
SVASYENEGVTGTPVAPAGRRLRPILGSADPVWS
PPEAACEDADEDDYEEDYNNEGYLVVLPDRDPAT
STGNAVSPAPASSKPGLRDSAFSMESGEDYVNVP
ESEESADASLNGSREYVNVSQELQPGAKTKPDTQ
NSQEVEDEEAPDYENL
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